2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140860
    Trityl-PEG8-azide 1818294-30-2
    Trityl-PEG8-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Trityl-PEG8-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Trityl-PEG8-azide
  • HY-140486
    Acid-PEG6-mono-methyl ester 1807512-38-4
    Acid-PEG6-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG6-mono-methyl ester
  • HY-140074
    endo-BCN-PEG4-Boc 1807501-83-2
    endo-BCN-PEG4-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    endo-BCN-PEG4-Boc
  • HY-138471
    Azido-PEG2-C6-OH
    Azido-PEG2-C6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C6-OH
  • HY-141311
    m-PEG4-phosphonic acid ethyl ester 1872433-73-2
    m-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-phosphonic acid ethyl ester
  • HY-140912
    Biotin-PEG11-azide 2276672-04-7
    Biotin-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG11-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG11-azide
  • HY-138330
    Fmoc-PEG5-NHBoc
    Fmoc-PEG5-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG5-NHBoc
  • HY-W096131
    Chloro-PEG5-chloride 5197-65-9
    Chloro-PEG5-chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Chloro-PEG5-chloride
  • HY-W096070
    Benzyl-PEG6-azide 86770-73-2
    Benzyl-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzyl-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzyl-PEG6-azide
  • HY-141080
    Fluorescein-PEG3-amine 1807539-04-3
    Fluorescein-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fluorescein-PEG3-amine
  • HY-141162
    TCO-PEG12-acid
    TCO-PEG12-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG12-acid
  • HY-140539
    N-Boc-N-bis(PEG3-acid) 2055023-35-1
    N-Boc-N-bis(PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-N-bis(PEG3-acid)
  • HY-138457
    Azido-PEG20-Boc
    Azido-PEG20-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG20-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG20-Boc
  • HY-143830
    t-Boc-N-amido-PEG2-C6-Cl 920264-35-3
    t-Boc-N-amido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-N-amido-PEG2-C6-Cl
  • HY-141356
    SPDP-PEG12-NHS ester 2601437-72-1
    SPDP-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    SPDP-PEG12-NHS ester
  • HY-141244
    Hydroxy-PEG3-acrylate 16695-45-7
    Hydroxy-PEG3-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG3-acrylate
  • HY-141068
    N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 2107273-58-3
    N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5
  • HY-140395
    Aminooxy-PEG8-acid 2055269-60-6
    Aminooxy-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG8-acid
  • HY-138465
    THP-C4-PEG4
    THP-C4-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-C4-PEG4
  • HY-140389
    PEG7-O-MS 1217601-12-1
    PEG7-O-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG7-O-MS
PROTAC Linkers Isoform Comparison

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